Targeting calcium cycling proteins in heart failure through gene transfer

Federica del Monte, Roger J. Hajjar

Research output: Contribution to journalReview articlepeer-review

81 Scopus citations

Abstract

Our understanding of cardiac excitation-contraction coupling has improved significantly over the last 10 years. Furthermore, defects in the various steps of excitation-contraction coupling that characterize cardiac dysfunction have been identified in human and experimental models of heart failure. The various abnormalities in ionic channels, transporters, kinases and various signalling pathways collectively contribute to the 'failing phenotype.' However, deciphering the causative changes continues to be a challenge. An important tool in dissecting the importance of the various changes in heart failure has been the use of cardiac gene transfer. To achieve effective cardiac gene transfer a number of obstacles remain, including appropriate vectors for gene delivery, appropriate delivery systems, and a better understanding of the biology of the disease. In this review, we will examine our current understanding of these various factors. Gene transfer provides not only a potential therapeutic modality but also an approach to identifying and validating molecular targets.

Original languageEnglish
Pages (from-to)49-61
Number of pages13
JournalJournal of Physiology
Volume546
Issue number1
DOIs
StatePublished - 1 Jan 2003
Externally publishedYes

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