Targeted labeling of an early-stage tumor spheroid in a chorioallantoic membrane model with upconversion nanoparticles

Kai Liu, Jasmin A. Holz, Yadan Ding, Xiaomin Liu, Youlin Zhang, Langping Tu, Xianggui Kong, Bram Priem, Annemarie Nadort, Saskia A.G. Lambrechts, Maurice C.G. Aalders, Wybren Jan Buma, Yichun Liu, Hong Zhang

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

In vivo detection of cancer at an early-stage, i.e. smaller than 2 mm, is a challenge in biomedicine. In this work target labeling of an early-stage tumor spheroid (∼500 μm) is realized for the first time in a chick embryo chorioallantoic membrane (CAM) model with monoclonal antibody functionalized upconversion nanoparticles (UCNPs-mAb).

Original languageEnglish
Pages (from-to)1596-1600
Number of pages5
JournalNanoscale
Volume7
Issue number5
DOIs
StatePublished - 7 Feb 2015
Externally publishedYes

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