TAM receptors and their ligand-mediated activation: Role in atherosclerosis

Bishuang Cai, Canan Kasikara

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations


TAM family tyrosine kinase receptors including Tyro3, Axl, and MerTK are the key efferocytosis receptors presenting on antigen-presenting cell that mediate the clearance of apoptotic cells. They are thought to regulate inflammatory diseases by modulating inflammatory response and efferocytosis. Recent studies have revealed novel roles of TAM receptors in the biosynthesis of specialized pro-resolving mediators (SPMs) and inflammation resolution. In this chapter, we discuss the central roles of TAM signaling in atherosclerosis focusing on their regulation in efferocytosis and inflammation resolution and highlight the unique therapeutic potential of SPMs in blocking the progression of atherosclerosis.

Original languageEnglish
Title of host publicationTAM Receptors in Health and Disease
EditorsViralkumar Davra, Lorenzo Galluzzi
PublisherElsevier Inc.
Number of pages13
ISBN (Print)9780128218228
StatePublished - Jan 2020

Publication series

NameInternational Review of Cell and Molecular Biology
ISSN (Print)1937-6448


  • Atherosclerosis
  • Efferocytosis
  • Inflammation resolution
  • MerTK cleavage
  • Specialized pro-resolving mediators
  • TAM


Dive into the research topics of 'TAM receptors and their ligand-mediated activation: Role in atherosclerosis'. Together they form a unique fingerprint.

Cite this