Taking it up a notch in MCL

Samir Parekh

doi:10.1182/blood-2012-01-403626

Taking it up a notch in MCL

Samir Parekh

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

In this issue of Blood, Kridel et al describe recurrent NOTCH1 mutations in mantle cell lymphoma (MCL) by next-generation sequencing of patient samples and cell lines. They further demonstrate a negative prognostic impact of NOTCH1 mutation in their cohort of patients and sensitivity of MCL cells to NOTCH1 inhibition in vitro, suggesting a novel role for NOTCH1 in this disease.

Original language	English
Pages (from-to)	1957-1958
Number of pages	2
Journal	Blood
Volume	119
Issue number	9
DOIs	https://doi.org/10.1182/blood-2012-01-403626
State	Published - 1 Mar 2012
Externally published	Yes

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title = "Taking it up a notch in MCL",

abstract = "In this issue of Blood, Kridel et al describe recurrent NOTCH1 mutations in mantle cell lymphoma (MCL) by next-generation sequencing of patient samples and cell lines. They further demonstrate a negative prognostic impact of NOTCH1 mutation in their cohort of patients and sensitivity of MCL cells to NOTCH1 inhibition in vitro, suggesting a novel role for NOTCH1 in this disease.",

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AB - In this issue of Blood, Kridel et al describe recurrent NOTCH1 mutations in mantle cell lymphoma (MCL) by next-generation sequencing of patient samples and cell lines. They further demonstrate a negative prognostic impact of NOTCH1 mutation in their cohort of patients and sensitivity of MCL cells to NOTCH1 inhibition in vitro, suggesting a novel role for NOTCH1 in this disease.

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U2 - 10.1182/blood-2012-01-403626

DO - 10.1182/blood-2012-01-403626

M3 - Comment/debate

AN - SCOPUS:84857695434

SN - 0006-4971

VL - 119

SP - 1957

EP - 1958

JO - Blood

JF - Blood

IS - 9

ER -

Taking it up a notch in MCL

Abstract

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