Taking Aim at Glycolysis with CDK8 Inhibitors

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations


Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.

Original languageEnglish
Pages (from-to)281-282
Number of pages2
JournalTrends in Endocrinology and Metabolism
Issue number5
StatePublished - May 2018


  • CDK8
  • Mediator
  • cancer
  • chemical genetics
  • glycolysis
  • transcription


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