Taking Aim at Glycolysis with CDK8 Inhibitors

Robert P. Fisher

doi:10.1016/j.tem.2018.02.005

Taking Aim at Glycolysis with CDK8 Inhibitors

Robert P. Fisher

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.

Original language	English
Pages (from-to)	281-282
Number of pages	2
Journal	Trends in Endocrinology and Metabolism
Volume	29
Issue number	5
DOIs	https://doi.org/10.1016/j.tem.2018.02.005
State	Published - May 2018

Keywords

CDK8
Mediator
cancer
chemical genetics
glycolysis
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10.1016/j.tem.2018.02.005

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@article{7e3342503f39403e969ca0747c542845,

title = "Taking Aim at Glycolysis with CDK8 Inhibitors",

abstract = "Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.",

keywords = "CDK8, Mediator, cancer, chemical genetics, glycolysis, transcription",

author = "Fisher, {Robert P.}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = may,

doi = "10.1016/j.tem.2018.02.005",

language = "English",

volume = "29",

pages = "281--282",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Inc.",

number = "5",

}

TY - JOUR

T1 - Taking Aim at Glycolysis with CDK8 Inhibitors

AU - Fisher, Robert P.

PY - 2018/5

Y1 - 2018/5

N2 - Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.

AB - Dependence on glycolysis under aerobic conditions, a frequent metabolic derangement in cancer cells, suggests a therapeutic opportunity. Now, through chemical genetics, CDK8, a kinase associated with the Mediator transcriptional coactivator complex, has emerged as an upstream inducer of glycolysis and a possible target for anticancer drug discovery.

KW - CDK8

KW - Mediator

KW - cancer

KW - chemical genetics

KW - glycolysis

KW - transcription

UR - http://www.scopus.com/inward/record.url?scp=85042193893&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2018.02.005

DO - 10.1016/j.tem.2018.02.005

M3 - Short survey

C2 - 29475579

AN - SCOPUS:85042193893

SN - 1043-2760

VL - 29

SP - 281

EP - 282

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 5

ER -

Taking Aim at Glycolysis with CDK8 Inhibitors

Abstract

Keywords

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