Tacrolimus time-in-therapeutic range is associated with freedom from acute rejection and graft failure following intestinal transplantation

Andrew D. Santeusanio, Alan Gu, Alan D. Weinberg, Jang Moon, Kishore R. Iyer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background: Trough-adjusted tacrolimus is commonly prescribed following intestinal transplantation to prevent allograft rejection. Despite established practice, there remains limited direct evidence linking tacrolimus levels with improved clinical outcomes. Methods: This was a single-center review of all adult non-liver containing intestinal allograft recipients from 2011 to 2018. Patients received lymphocyte depleting induction and maintenance immunosuppression consisting of tacrolimus and a corticosteroid taper. Tacrolimus time-in-therapeutic range (TAC-TTR) was calculated for all patients from the date of transplant until 1-year post-transplant using Rosendaal's method. Cox-Proportional hazards modeling was utilized to assess freedom from acute rejection and graft failure stratified by TAC-TTR quartile. Results: 47 patients were included in the review. Mean TAC-TTR for the cohort was 30.2% ± 11.4. Fifteen episodes of acute rejection were observed, 8 of which were severe. Patients in the highest TAC-TTR quartile >36% had a lower incidence of acute rejection and graft failure relative to patients with a TAC-TTR <20%. Cox-Proportional hazards modeling found a 10% decrease in TAC-TTR was associated with an increased hazard for acute rejection (2.03), severe acute rejection (2.19), and graft loss (3.33). Conclusion: The results of this study suggest that decreasing TAC-TTR is a risk factor for both acute rejection as well as intestinal allograft failure.

Original languageEnglish
Article numbere14291
JournalClinical Transplantation
Volume35
Issue number6
DOIs
StatePublished - Jun 2021

Keywords

  • drug monitoring
  • graft rejection
  • immunosuppression
  • intestinal transplantation
  • tacrolimus

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