t(3;22)(q27;q11): A novel translocation associated with diffuse non-Hodgkin's lymphoma

K. Offit, S. Jhanwar, S. A.D. Ebrahim, D. Filippa, B. D. Clarkson, R. S.K. Chaganti

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110 Scopus citations


Of 187 specimens of non-Hodgkin's lymphoma and four hyperplastic lymphoid proliferations with clonal chromosome abnormalities ascertained serially over a 4 1/2 -year period, nine cases with t(3;22)(q27;q11) were identified. Seven of the lymphomas were diffuse tumors, predominantly of large cell type. The eighth tumor, a follicular small cleaved cell lymphoma, exhibited a t(3;22) and a t(14;18)(q32;q21). The ninth case was a lymph node from a human immunodeficiency virus-positive patient which showed atypical hyperplasia. Overall survival of t(3;22) diffuse lymphoma patients was not different from that of patients with abnormal karyotypes without t(3;22). The t(3;22) diffuse tumors studied showed a disproportionate frequency of λ light chain on their cell surfaces, a finding similar to that observed in t(8;22)(q24;q11) Burkitt's lymphomas. Our results indicate that the t(3;22)(q27;q11) is the third most common recurring translocation in diffuse non-Hodgkin's lymphoma.

Original languageEnglish
Pages (from-to)1876-1879
Number of pages4
Issue number6
StatePublished - 1989
Externally publishedYes


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