T1Ρ Mapping and Its Applications for Assessment of Renal Fibrosis

Octavia Bane; Sara Lewis

doi:10.1007/978-3-031-40169-5_11

T1Ρ Mapping and Its Applications for Assessment of Renal Fibrosis

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

In renal MRI, measurement of the spin-lattice relaxation time of water molecules in the rotating frame (T1Ρ) may provide a valuable biomarker for kidney fibrosis. Due to the sensitivity of T1Ρ to the interactions of free water molecules to macromolecules such as collagen, there is substantial interest in mapping T1Ρ for noninvasive imaging of renal fibrosis, which is accompanied by collagen deposition. Unlike other MRI-based markers of tissue fibrosis, T1Ρ is not affected by blood flow, perfusion, or inflammation, which enhances its attractiveness as a noninvasive and specific biomarker of kidney fibrosis. In this chapter, we will discuss the physical principles of T1Ρ mapping, different pulse sequence implementations, data acquisition and analysis methods, followed by an overview of emerging applications of T1Ρ imaging of kidney disease.

Original language	English
Title of host publication	Advanced Clinical MRI of the Kidney
Subtitle of host publication	Methods and Protocols
Publisher	Springer International Publishing
Pages	153-162
Number of pages	10
ISBN (Electronic)	9783031401695
ISBN (Print)	9783031401688
DOIs	https://doi.org/10.1007/978-3-031-40169-5_11
State	Published - 1 Jan 2023

Access to Document

10.1007/978-3-031-40169-5_11

Cite this

@inbook{6d64ca1f250547e8a35f3ecaf0860021,

title = "T1Ρ Mapping and Its Applications for Assessment of Renal Fibrosis",

abstract = "In renal MRI, measurement of the spin-lattice relaxation time of water molecules in the rotating frame (T1Ρ) may provide a valuable biomarker for kidney fibrosis. Due to the sensitivity of T1Ρ to the interactions of free water molecules to macromolecules such as collagen, there is substantial interest in mapping T1Ρ for noninvasive imaging of renal fibrosis, which is accompanied by collagen deposition. Unlike other MRI-based markers of tissue fibrosis, T1Ρ is not affected by blood flow, perfusion, or inflammation, which enhances its attractiveness as a noninvasive and specific biomarker of kidney fibrosis. In this chapter, we will discuss the physical principles of T1Ρ mapping, different pulse sequence implementations, data acquisition and analysis methods, followed by an overview of emerging applications of T1Ρ imaging of kidney disease.",

author = "Octavia Bane and Sara Lewis",

note = "Publisher Copyright: {\textcopyright} The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.",

year = "2023",

month = jan,

day = "1",

doi = "10.1007/978-3-031-40169-5_11",

language = "English",

isbn = "9783031401688",

pages = "153--162",

booktitle = "Advanced Clinical MRI of the Kidney",

publisher = "Springer International Publishing",

}

TY - CHAP

T1 - T1Ρ Mapping and Its Applications for Assessment of Renal Fibrosis

AU - Bane, Octavia

AU - Lewis, Sara

N1 - Publisher Copyright: © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - In renal MRI, measurement of the spin-lattice relaxation time of water molecules in the rotating frame (T1Ρ) may provide a valuable biomarker for kidney fibrosis. Due to the sensitivity of T1Ρ to the interactions of free water molecules to macromolecules such as collagen, there is substantial interest in mapping T1Ρ for noninvasive imaging of renal fibrosis, which is accompanied by collagen deposition. Unlike other MRI-based markers of tissue fibrosis, T1Ρ is not affected by blood flow, perfusion, or inflammation, which enhances its attractiveness as a noninvasive and specific biomarker of kidney fibrosis. In this chapter, we will discuss the physical principles of T1Ρ mapping, different pulse sequence implementations, data acquisition and analysis methods, followed by an overview of emerging applications of T1Ρ imaging of kidney disease.

AB - In renal MRI, measurement of the spin-lattice relaxation time of water molecules in the rotating frame (T1Ρ) may provide a valuable biomarker for kidney fibrosis. Due to the sensitivity of T1Ρ to the interactions of free water molecules to macromolecules such as collagen, there is substantial interest in mapping T1Ρ for noninvasive imaging of renal fibrosis, which is accompanied by collagen deposition. Unlike other MRI-based markers of tissue fibrosis, T1Ρ is not affected by blood flow, perfusion, or inflammation, which enhances its attractiveness as a noninvasive and specific biomarker of kidney fibrosis. In this chapter, we will discuss the physical principles of T1Ρ mapping, different pulse sequence implementations, data acquisition and analysis methods, followed by an overview of emerging applications of T1Ρ imaging of kidney disease.

UR - http://www.scopus.com/inward/record.url?scp=85195970815&partnerID=8YFLogxK

U2 - 10.1007/978-3-031-40169-5_11

DO - 10.1007/978-3-031-40169-5_11

M3 - Chapter

AN - SCOPUS:85195970815

SN - 9783031401688

SP - 153

EP - 162

BT - Advanced Clinical MRI of the Kidney

PB - Springer International Publishing

ER -

T1Ρ Mapping and Its Applications for Assessment of Renal Fibrosis

Abstract

Access to Document

Fingerprint

Cite this