TY - JOUR
T1 - T regulatory cells and transplantation tolerance
AU - Gorantla, Vijay S.
AU - Schneeberger, Stefan
AU - Brandacher, Gerald
AU - Sucher, Robert
AU - Zhang, Dong
AU - Lee, W. P.Andrew
AU - Zheng, Xin Xiao
PY - 2010/7
Y1 - 2010/7
N2 - Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation.The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.
AB - Despite the development of successful immunosuppression protocols and tremendous improvement in short-term graft survival rates, the problem of chronic graft loss remains the bane of clinical transplantation. The induction and maintenance of transplantation tolerance is the "Holy Grail" of transplantation.The recent identification and characterization of regulatory T cells has opened up exciting opportunities for tolerance induction, immunotherapy, and immunomodulation in transplantation. This review focuses on current understanding of regulatory T cells and their role in transplantation tolerance.
UR - http://www.scopus.com/inward/record.url?scp=77954383661&partnerID=8YFLogxK
U2 - 10.1016/j.trre.2010.04.002
DO - 10.1016/j.trre.2010.04.002
M3 - Review article
C2 - 20541385
AN - SCOPUS:77954383661
SN - 0955-470X
VL - 24
SP - 147
EP - 159
JO - Transplantation Reviews
JF - Transplantation Reviews
IS - 3
ER -