T cells in celiac disease

Bana Jabri, Ludvig M. Sollid

Research output: Contribution to journalReview articlepeer-review

163 Scopus citations

Abstract

Celiac disease is a human T cell mediated autoimmunelike disorder caused by exposure to dietary gluten in genetically predisposed individuals. This review will discuss how CD4 T cell responses directed against an exogenous Ag can cause an autoreactive B cell response and participate in the licensing of intraepithelial lymphocytes to kill intestinal epithelial cells. Furthermore, this review will examine the mechanisms by which intraepithelial cytotoxic T cells mediate tissue destruction in celiac disease. The Journal of Immunology, 2017, 198: 3005-3014.

Original languageEnglish
Pages (from-to)3005-3014
Number of pages10
JournalJournal of Immunology
Volume198
Issue number8
DOIs
StatePublished - 15 Apr 2017
Externally publishedYes

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