T cells from patients with Parkinson's disease recognize α-synuclein peptides

David Sulzer; Roy N. Alcalay; Francesca Garretti; Lucien Cote; Ellen Kanter; Julian Agin-Liebes; Christopher Liong; Curtis McMurtrey; William H. Hildebrand; Xiaobo Mao; Valina L. Dawson; Ted M. Dawson; Carla Oseroff; John Pham; John Sidney; Myles B. Dillon; Chelsea Carpenter; Daniela Weiskopf; Elizabeth Phillips; Simon Mallal; Bjoern Peters; April Frazier; Cecilia S. Lindestam Arlehamn; Alessandro Sette

doi:10.1038/nature22815

T cells from patients with Parkinson's disease recognize α-synuclein peptides

David Sulzer
, Roy N. Alcalay
, Francesca Garretti
, Lucien Cote
, Ellen Kanter
, Julian Agin-Liebes
, Christopher Liong
, Curtis McMurtrey
, William H. Hildebrand
, Xiaobo Mao
, Valina L. Dawson
, Ted M. Dawson
, Carla Oseroff
, John Pham
, John Sidney
, Myles B. Dillon
, Chelsea Carpenter
, Daniela Weiskopf
, Elizabeth Phillips
, Simon Mallal

Bjoern Peters, April Frazier, Cecilia S. Lindestam Arlehamn, Alessandro Sette

Research output: Contribution to journal › Article › peer-review

686 Scopus citations

Abstract

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

Original language	English
Pages (from-to)	656-661
Number of pages	6
Journal	Nature
Volume	546
Issue number	7660
DOIs	https://doi.org/10.1038/nature22815
State	Published - 29 Jun 2017
Externally published	Yes

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Sulzer, D., Alcalay, R. N., Garretti, F., Cote, L., Kanter, E., Agin-Liebes, J., Liong, C., McMurtrey, C., Hildebrand, W. H., Mao, X., Dawson, V. L., Dawson, T. M., Oseroff, C., Pham, J., Sidney, J., Dillon, M. B., Carpenter, C., Weiskopf, D., Phillips, E., ... Sette, A. (2017). T cells from patients with Parkinson's disease recognize α-synuclein peptides. Nature, 546(7660), 656-661. https://doi.org/10.1038/nature22815

@article{ef5ea22dde324afabc2dab22602ed0ac,

title = "T cells from patients with Parkinson's disease recognize α-synuclein peptides",

abstract = "Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.",

author = "David Sulzer and Alcalay, \{Roy N.\} and Francesca Garretti and Lucien Cote and Ellen Kanter and Julian Agin-Liebes and Christopher Liong and Curtis McMurtrey and Hildebrand, \{William H.\} and Xiaobo Mao and Dawson, \{Valina L.\} and Dawson, \{Ted M.\} and Carla Oseroff and John Pham and John Sidney and Dillon, \{Myles B.\} and Chelsea Carpenter and Daniela Weiskopf and Elizabeth Phillips and Simon Mallal and Bjoern Peters and April Frazier and \{Lindestam Arlehamn\}, \{Cecilia S.\} and Alessandro Sette",

year = "2017",

month = jun,

day = "29",

doi = "10.1038/nature22815",

language = "English",

volume = "546",

pages = "656--661",

journal = "Nature",

issn = "0028-0836",

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Sulzer, D, Alcalay, RN, Garretti, F, Cote, L, Kanter, E, Agin-Liebes, J, Liong, C, McMurtrey, C, Hildebrand, WH, Mao, X, Dawson, VL, Dawson, TM, Oseroff, C, Pham, J, Sidney, J, Dillon, MB, Carpenter, C, Weiskopf, D, Phillips, E, Mallal, S, Peters, B, Frazier, A, Lindestam Arlehamn, CS & Sette, A 2017, 'T cells from patients with Parkinson's disease recognize α-synuclein peptides', Nature, vol. 546, no. 7660, pp. 656-661. https://doi.org/10.1038/nature22815

TY - JOUR

T1 - T cells from patients with Parkinson's disease recognize α-synuclein peptides

AU - Sulzer, David

AU - Alcalay, Roy N.

AU - Garretti, Francesca

AU - Cote, Lucien

AU - Kanter, Ellen

AU - Agin-Liebes, Julian

AU - Liong, Christopher

AU - McMurtrey, Curtis

AU - Hildebrand, William H.

AU - Mao, Xiaobo

AU - Dawson, Valina L.

AU - Dawson, Ted M.

AU - Oseroff, Carla

AU - Pham, John

AU - Sidney, John

AU - Dillon, Myles B.

AU - Carpenter, Chelsea

AU - Weiskopf, Daniela

AU - Phillips, Elizabeth

AU - Mallal, Simon

AU - Peters, Bjoern

AU - Frazier, April

AU - Lindestam Arlehamn, Cecilia S.

AU - Sette, Alessandro

PY - 2017/6/29

Y1 - 2017/6/29

N2 - Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

AB - Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the association of Parkinson's disease with specific major histocompatibility complex alleles.

UR - https://www.scopus.com/pages/publications/85021661653

U2 - 10.1038/nature22815

DO - 10.1038/nature22815

M3 - Article

C2 - 28636593

AN - SCOPUS:85021661653

SN - 0028-0836

VL - 546

SP - 656

EP - 661

JO - Nature

JF - Nature

IS - 7660

ER -

T cells from patients with Parkinson's disease recognize α-synuclein peptides

Abstract

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