TY - JOUR
T1 - T-cell receptors in ataxia⇓telangiectasia
AU - Holcombe, Randall F.
AU - Aparicio, Pedro
AU - Alonso, Jose Maria
AU - Perez, Paloma
AU - Arnaiz, Antonio
AU - Martinez-A, Carlos
PY - 1990/10/25
Y1 - 1990/10/25
N2 - To the Editor: With reference to the article by Carbonari and colleagues (Jan. 11 issue) describing a relative increase in γ/δ T cells in patients with ataxia—telangiectasia,1 recent work by me and my collaborators has demonstrated a similar relative increase in these cells in the peripheral blood of patients with the Chédiak—Higashi syndrome. This is an immunodeficiency disorder involving impairment of cytotoxic activity, which is characterized by large, abnormal lysosomal granules in all granule-containing cells.2 The mean (±SD) ratio of γ/δ-bearing cells to α/β-bearing cells in patients with ataxia—telangiectasia (n = 10)1 is 0.230±0.190 (range, 0.075 to 0.600), and the.
AB - To the Editor: With reference to the article by Carbonari and colleagues (Jan. 11 issue) describing a relative increase in γ/δ T cells in patients with ataxia—telangiectasia,1 recent work by me and my collaborators has demonstrated a similar relative increase in these cells in the peripheral blood of patients with the Chédiak—Higashi syndrome. This is an immunodeficiency disorder involving impairment of cytotoxic activity, which is characterized by large, abnormal lysosomal granules in all granule-containing cells.2 The mean (±SD) ratio of γ/δ-bearing cells to α/β-bearing cells in patients with ataxia—telangiectasia (n = 10)1 is 0.230±0.190 (range, 0.075 to 0.600), and the.
UR - http://www.scopus.com/inward/record.url?scp=0025049631&partnerID=8YFLogxK
U2 - 10.1056/NEJM199010253231714
DO - 10.1056/NEJM199010253231714
M3 - Letter
C2 - 2215600
AN - SCOPUS:0025049631
SN - 0028-4793
VL - 323
SP - 1210
EP - 1211
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 17
ER -