Systemic sclerosis

Maritza I. Perez, Steven R. Kohn

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Systemic sclerosis affects the connective tissue of various organs. It is characterized by alteration of the microvasculature with a dense inflammatory cellular infiltrate, followed by massive deposition of collagen. This review discusses diagnostic criteria, clinical subsets, survival data, clinical evaluation, epidemiology, pathogenesis, immunobiology, genetics, and therapy for systemic sclerosis in adults. Because the diagnosis of systemic sclerosis is most dependent on its cutaneous involvement, knowledge of this is essential in the evaluation and management of patients with this disorder.

Original languageEnglish
Pages (from-to)525-547
Number of pages23
JournalJournal of the American Academy of Dermatology
Issue number4
StatePublished - 1993
Externally publishedYes


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