Systemic Regulation of Local Cell Competition

Susumu Hirabayashi; Ross Cagan

doi:10.1016/j.devcel.2020.04.020

Systemic Regulation of Local Cell Competition

Susumu Hirabayashi, Ross Cagan

Research output: Contribution to journal › Comment/debate

Abstract

Somatic scribble mutant cells are selectively eliminated from the growing Drosophila tissue through cell competition, a tumor-suppressing mechanism that ensures tissue integrity. In this issue of Developmental Cell, Sanaki et al. demonstrate that organismal hyperinsulinemia promotes tumorigenesis by abrogating local cell competition.

Original language	English
Pages (from-to)	371-372
Number of pages	2
Journal	Developmental Cell
Volume	53
Issue number	4
DOIs	https://doi.org/10.1016/j.devcel.2020.04.020
State	Published - 18 May 2020
Externally published	Yes

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title = "Systemic Regulation of Local Cell Competition",

abstract = "Somatic scribble mutant cells are selectively eliminated from the growing Drosophila tissue through cell competition, a tumor-suppressing mechanism that ensures tissue integrity. In this issue of Developmental Cell, Sanaki et al. demonstrate that organismal hyperinsulinemia promotes tumorigenesis by abrogating local cell competition.",

author = "Susumu Hirabayashi and Ross Cagan",

note = "Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = may,

day = "18",

doi = "10.1016/j.devcel.2020.04.020",

language = "English",

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journal = "Developmental Cell",

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AU - Hirabayashi, Susumu

AU - Cagan, Ross

PY - 2020/5/18

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AB - Somatic scribble mutant cells are selectively eliminated from the growing Drosophila tissue through cell competition, a tumor-suppressing mechanism that ensures tissue integrity. In this issue of Developmental Cell, Sanaki et al. demonstrate that organismal hyperinsulinemia promotes tumorigenesis by abrogating local cell competition.

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U2 - 10.1016/j.devcel.2020.04.020

DO - 10.1016/j.devcel.2020.04.020

M3 - Comment/debate

C2 - 32428451

AN - SCOPUS:85084393122

SN - 1534-5807

VL - 53

SP - 371

EP - 372

JO - Developmental Cell

JF - Developmental Cell

IS - 4

ER -

Systemic Regulation of Local Cell Competition

Abstract

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