Systemic hemodynamic atherothrombotic syndrome: from hypothesis to evidence

Yusuke Ishiyama, Satoshi Hoshide, Kazuomi Kario

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Hypertension is a risk factor for cardiovascular disease (CVD). However, the association between blood pressure (BP) and CVD events has been based on mean BP alone. BP variability (BPV) is associated with increased organ damage and CVD events independently or beyond average home BP. To explain this association, we propose the systemic hemodynamic atherothrombotic syndrome (SHATS) hypothesis. The SHATS hypothesis indicates that hemodynamic stress increases vascular disease and vice versa, leading to a vicious cycle of the association between hemodynamic stress and a vascular disease; this association provides not only the risk but also the trigger for CVD events. The evidences of SHATS were gradually accumulating. We showed arterial stiffness synergistically amplified the association between hemodynamic stress and cardiac overload / CVD events in patients with at least one CVD risk factor. (Figure presented.)

Original languageEnglish
Pages (from-to)579-585
Number of pages7
JournalHypertension Research
Issue number3
StatePublished - Mar 2024
Externally publishedYes


  • Arterial stiffness
  • Blood pressure variability
  • Cardiovascular disease
  • Organ damage
  • Systemic hemodynamic atherothrombotic syndrome


Dive into the research topics of 'Systemic hemodynamic atherothrombotic syndrome: from hypothesis to evidence'. Together they form a unique fingerprint.

Cite this