Systemic chemotherapy decreases brain glucose metabolism

Laura L. Horky, Victor H. Gerbaudo, Alexander Zaitsev, Wen Plesniak, Jon Hainer, Usha Govindarajulu, Ron Kikinis, Jörg Dietrich

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Objective: Cancer patients may experience neurologic adverse effects, such as alterations in neurocognitive function, as a consequence of chemotherapy. The mechanisms underlying such neurotoxic syndromes remain poorly understood. We here describe the temporal and regional effects of systemically administered platinum-based chemotherapy on glucose metabolism in the brain of cancer patients. Methods: Using sequential FDG-PET/CT imaging prior to and after administration of chemotherapy, we retrospectively characterized the effects of intravenously administered chemotherapy on brain glucose metabolism in a total of 24 brain regions in a homogenous cohort of 10 patients with newly diagnosed non-small-cell lung cancer. Results: Significant alterations of glucose metabolism were found in response to chemotherapy in all gray matter structures, including cortical structures, deep nuclei, hippocampi, and cerebellum. Metabolic changes were also notable in frontotemporal white matter (WM) network systems, including the corpus callosum, subcortical, and periventricular WM tracts. Interpretation: Our data demonstrate a decrease in glucose metabolism in both gray and white matter structures associated with chemotherapy. Among the affected regions are those relevant to the maintenance of brain plasticity and global neurologic function. This study potentially offers novel insights into the spatial and temporal effects of systemic chemotherapy on brain metabolism in cancer patients.

Original languageEnglish
Pages (from-to)788-798
Number of pages11
JournalAnnals of Clinical and Translational Neurology
Volume1
Issue number10
DOIs
StatePublished - Oct 2014
Externally publishedYes

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