Systemic 1-methyl, 4-phenyl, 1-2-3-6-tetrahydropyridine (MPTP) administration decreases retinal dopamine content in primates

M. Felice Ghilardi; Eunyong Chung; Ivan Bodis-Wollner; Mark Dvorzniak; Andrew Glover; Marco Onofrj

doi:10.1016/0024-3205(88)90315-3

Systemic 1-methyl, 4-phenyl, 1-2-3-6-tetrahydropyridine (MPTP) administration decreases retinal dopamine content in primates

M. Felice Ghilardi, Eunyong Chung, Ivan Bodis-Wollner, Mark Dvorzniak, Andrew Glover, Marco Onofrj

Icahn School of Medicine at Mount Sinai

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Following MPTP administration, 4 Cynomolgus monkeys developed a parkinsonian syndrome, accompanied by specific changes of both pattern visual evoked potential and electroretinogram. Retinal dopamine and dihydroxyphenylacetic acid contents were measured in the 4 MPTP-treated monkeys and in 3 normal monkeys. Dopamine and dihydroxyphenylacetic acid levels were significantly lower in the retinas of the MPTP-treated animals (p<0.001), suggesting that dopamine has a specific function in the visual system of primates.

Original language	English
Pages (from-to)	255-262
Number of pages	8
Journal	Life Sciences
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/0024-3205(88)90315-3
State	Published - 1988

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@article{5909ea0961104efd822b3cd7b8799929,

title = "Systemic 1-methyl, 4-phenyl, 1-2-3-6-tetrahydropyridine (MPTP) administration decreases retinal dopamine content in primates",

abstract = "Following MPTP administration, 4 Cynomolgus monkeys developed a parkinsonian syndrome, accompanied by specific changes of both pattern visual evoked potential and electroretinogram. Retinal dopamine and dihydroxyphenylacetic acid contents were measured in the 4 MPTP-treated monkeys and in 3 normal monkeys. Dopamine and dihydroxyphenylacetic acid levels were significantly lower in the retinas of the MPTP-treated animals (p<0.001), suggesting that dopamine has a specific function in the visual system of primates.",

author = "{Felice Ghilardi}, M. and Eunyong Chung and Ivan Bodis-Wollner and Mark Dvorzniak and Andrew Glover and Marco Onofrj",

note = "Funding Information: was supported by NIH grants and a grant from Sigma-Tau.",

year = "1988",

doi = "10.1016/0024-3205(88)90315-3",

language = "English",

volume = "43",

pages = "255--262",

journal = "Life Sciences",

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T1 - Systemic 1-methyl, 4-phenyl, 1-2-3-6-tetrahydropyridine (MPTP) administration decreases retinal dopamine content in primates

AU - Felice Ghilardi, M.

AU - Chung, Eunyong

AU - Bodis-Wollner, Ivan

AU - Dvorzniak, Mark

AU - Glover, Andrew

AU - Onofrj, Marco

N1 - Funding Information: was supported by NIH grants and a grant from Sigma-Tau.

PY - 1988

Y1 - 1988

N2 - Following MPTP administration, 4 Cynomolgus monkeys developed a parkinsonian syndrome, accompanied by specific changes of both pattern visual evoked potential and electroretinogram. Retinal dopamine and dihydroxyphenylacetic acid contents were measured in the 4 MPTP-treated monkeys and in 3 normal monkeys. Dopamine and dihydroxyphenylacetic acid levels were significantly lower in the retinas of the MPTP-treated animals (p<0.001), suggesting that dopamine has a specific function in the visual system of primates.

AB - Following MPTP administration, 4 Cynomolgus monkeys developed a parkinsonian syndrome, accompanied by specific changes of both pattern visual evoked potential and electroretinogram. Retinal dopamine and dihydroxyphenylacetic acid contents were measured in the 4 MPTP-treated monkeys and in 3 normal monkeys. Dopamine and dihydroxyphenylacetic acid levels were significantly lower in the retinas of the MPTP-treated animals (p<0.001), suggesting that dopamine has a specific function in the visual system of primates.

UR - http://www.scopus.com/inward/record.url?scp=0023782223&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(88)90315-3

DO - 10.1016/0024-3205(88)90315-3

M3 - Article

C2 - 3260986

AN - SCOPUS:0023782223

SN - 0024-3205

VL - 43

SP - 255

EP - 262

JO - Life Sciences

JF - Life Sciences

IS - 3

ER -

Systemic 1-methyl, 4-phenyl, 1-2-3-6-tetrahydropyridine (MPTP) administration decreases retinal dopamine content in primates

Abstract

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