Systematische review: transcraniële magnetische stimulatie voor obsessieve-compulsieve stoornis

Translated title of the contribution: Transcranial magnetic stimulation in obsessive compulsive disorder: A systematic review

A. M. Euser, A. F. Stapert, M. Oosterhoff, I. D.C. Van Balkom, M. Figee

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


background Ten per cent of patients with obsessive-compulsive disorder (ocd) are resistant to treatment. For these patients, repetitive transcranial magnetic stimulation (itms) may be an alternative form of treatment. aim To clarify the effect and clinical application of ítms for treatment-resistant ocd. method We searched the literature systematically and we discuss the relevant articles critically. results We included 17 randomised controlled trials (rcts) with 502 patients.The reported trials were small and heterogeneous. a small but consistent treatment effect was found for Itms (mean decrease y-bocs score 6.6 points) compared to placebo stimulation (mean decrease y-bocs score 2.4 points). However, the differences between the effects of itms and the effects of placebo were often not statistically or clinically significant. The effect frequently disappeared within several weeks after ending rTMS and the follow-up period was never longer than three months. conclusion rTMS is still not entirely suitable for inclusion in the regular treatment of resistant ocd. More information is needed about follow-up requirements and about the advisable length and intensity of the applied stimulation. Future developments may involve increasing the number of stimulation sessions, combining these with cognitive behavioral therapy and delivering a more personalised form of itms.

Translated title of the contributionTranscranial magnetic stimulation in obsessive compulsive disorder: A systematic review
Original languageDutch
Pages (from-to)617-625
Number of pages9
JournalTijdschrift voor Psychiatrie
Issue number10
StatePublished - Oct 2017
Externally publishedYes


  • Itms
  • Ocd
  • Review


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