Synthetic, non-natural analogs of ceramide elevate cellular ceramide, inducing apoptotic death to prostate cancer cells and eradicating tumors in mice

Jing Dong Qin, Lola Weiss, Shimon Slavin, Shimon Gatt, Arie Dagan

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The anticancer effects of synthetic, non-natural analogs of ceramide were tested using human TSU-Pr1 prostate cancer cells in-vitro as well as in-vivo, following their effects on tumors development in mice. When incubated with the cultured cancer cells, the analogs elevated cellular ceramide and induced a cytotoxicity and death by apoptosis. When a ceramide analog was injected intradermally or intraperitoneally into BALB/c-Nude or NOD-SCID mice bearing a human prostate tumor, a considerable regression of the tumor was observed. The synthetic ceramide analogs should thus be further investigated as potential anticancer drugs.

Original languageEnglish
Pages (from-to)535-543
Number of pages9
JournalCancer Investigation
Volume28
Issue number5
DOIs
StatePublished - May 2010
Externally publishedYes

Keywords

  • Apoptosis
  • Cancer
  • Ceramide
  • Prostate
  • Sphingolipids

Fingerprint

Dive into the research topics of 'Synthetic, non-natural analogs of ceramide elevate cellular ceramide, inducing apoptotic death to prostate cancer cells and eradicating tumors in mice'. Together they form a unique fingerprint.

Cite this