Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

Edward M. Rosser; Simon Morton; Kate S. Ashton; Philip Cohen; Alison N. Hulme

doi:10.1039/b311242j

Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

Edward M. Rosser
, Simon Morton
, Kate S. Ashton
, Philip Cohen
, Alison N. Hulme

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.

Original language	English
Pages (from-to)	142-149
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	2
Issue number	1
DOIs	https://doi.org/10.1039/b311242j
State	Published - 7 Jan 2004
Externally published	Yes

Access to Document

10.1039/b311242j

Cite this

@article{95756941d7ee43a48f99b6eb960d0bf3,

title = "Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways",

abstract = "The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.",

author = "Rosser, \{Edward M.\} and Simon Morton and Ashton, \{Kate S.\} and Philip Cohen and Hulme, \{Alison N.\}",

year = "2004",

month = jan,

day = "7",

doi = "10.1039/b311242j",

language = "English",

volume = "2",

pages = "142--149",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "1",

}

TY - JOUR

T1 - Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

AU - Rosser, Edward M.

AU - Morton, Simon

AU - Ashton, Kate S.

AU - Cohen, Philip

AU - Hulme, Alison N.

PY - 2004/1/7

Y1 - 2004/1/7

N2 - The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.

AB - The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated. The relative activation of the JNK/SAPK1 and p38/SAPK2 pathways in RAW macrophages by these analogues, and their synthetic precursors, has been assessed using immunoblot assays against phosphorylated c-Jun and MAPKAP-K2. These studies demonstrate that some of the synthetic C(4) analogues are also potent activators of these stress kinase pathways.

UR - https://www.scopus.com/pages/publications/1642461692

U2 - 10.1039/b311242j

DO - 10.1039/b311242j

M3 - Article

C2 - 14737674

AN - SCOPUS:1642461692

SN - 1477-0520

VL - 2

SP - 142

EP - 149

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 1

ER -

Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways

Abstract

Access to Document

Fingerprint

Cite this