@article{399bafe1154c4d1caa4e4544e68db910,
title = "Synthesis of the fused bicyclic lactam-lactone terminus of neooxazolomycin by a novel dianion cyclocondensation",
abstract = "Reaction of the dianion (5) derived from an acylaminomalonic ester with S-(-)-MOM lactate (6) yields β-hydroxylactams 7 and 8 in a 2:1 ratio. Deprotection and lactonization of 7, followed by saponification and 2 step carboxyl reduction efficiently produces the fused bicyclic lactam-lactone 12, a chiral model of the antitumor antibiotic neooxazolomycm 1.",
author = "Kende, {Andrew S.} and DeVita, {Robert J.}",
note = "Funding Information: ACKNOWLEDGMENT8 Partial support of this rwearch by grant CA 18846,a warded by the National Cancer Institute,N E-USPHS, is gratefully acknowledged.R JD thanks the University of Rochesterf or financial support in the form of a ShermanC larke FeIlowship.",
year = "1988",
doi = "10.1016/S0040-4039(00)86101-8",
language = "English",
volume = "29",
pages = "2521--2524",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "21",
}