The 3H‐labeling of clorgyline, L‐deprenyl, N,N‐dimethylphenethyl amine and N‐methylphenethyl amine as well as the 14C‐labeling of clorgyline and L‐deprenyl are described. Labeling was accomplished by N‐alkylation of the free base of the corresponding desmethyl compound, using 3H‐methyl iodide, or by a reductive alkylation using 14C‐formaldehyde. The crude products were purified by semipreparative HPLC. The total radiochemical yield was 31‐65% based on 3H‐methyl iodide and 60% based on 14C‐formaldehyde. The radiochemical purity was greater than 99%.
|Number of pages||8|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|State||Published - May 1988|
- N,N‐dimethylphenethyl amine
- N‐methylphenethyl amine