Synthesis of saponins using partially protected glycosyl donors

Yuguo Du, Guofeng Gu, Guohua Wei, Yuxia Hua, Robert J. Linhardt

Research output: Contribution to journalArticlepeer-review

55 Scopus citations

Abstract

(Matrix Presented) A new class of glycosyl donors having unprotected 2- and 2,4-hydroxyl groups were investigated under the standard glycosylation conditions. This approach was shown to be generally effective for the synthesis of alkyl and steroidal glycosides. A natural saponin, containing 2,4-branched oligosaccharide, was prepared in 35% overall yield in four straightforward sequential reactions by taking advantage of these partially protected donors.

Original languageEnglish
Pages (from-to)3627-3630
Number of pages4
JournalOrganic Letters
Volume5
Issue number20
DOIs
StatePublished - 2 Oct 2003
Externally publishedYes

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