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Synthesis of radiolabeled biphenylsulfonamide matrix metalloproteinase inhibitors as new potential PET cancer imaging agents

  • Xiangshu Fei
  • , Qi Huang Zheng
  • , Xuan Liu
  • , Ji Quan Wang
  • , Hui Bin Sun
  • , Bruce H. Mock
  • , K. Lee Stone
  • , Kathy D. Miller
  • , George W. Sledge
  • , Gary D. Hutchins

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Novel matrix metalloproteinase (MMP) inhibitor radiotracers, (S)-3-methyl-2-(2′,3′,4′-methoxybiphenyl-4-sulfonylamino)- butyric acid [11C]methyl ester (1a-c), (S)-3-methyl-2-(2′,3′,4′-fluorobiphenyl-4-sulfonylamino)- butyric acid [11C]methyl ester (1d-f), and (S)-3-methyl-2-(4′-nitrobiphenyl-4-sulfonylamino)-butyric acid [11C]methyl ester (1g), a series of substituted biphenylsulfonamide derivatives, have been synthesized for evaluation as new potential positron emission tomography (PET) cancer imaging agents.

Original languageEnglish
Pages (from-to)2217-2222
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number13
DOIs
StatePublished - 7 Jul 2003
Externally publishedYes

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