Synthesis of oxaspiropiperidines as a strategy for lowering logD

Timothy Cernak; Kevin Dykstra; Dorothy Levorse; Andreas Verras; James Balkovec; Ravi Nargund; Robert DeVita

doi:10.1016/j.tetlet.2011.09.100

Synthesis of oxaspiropiperidines as a strategy for lowering logD

Timothy Cernak
, Kevin Dykstra
, Dorothy Levorse
, Andreas Verras
, James Balkovec
, Ravi Nargund
, Robert DeVita

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The syntheses of four new spiropiperidines designed as polar analogs of methyl 2-(3-azaspiro[5.5]undec-an-9-yl)acetate are described.

Original language	English
Pages (from-to)	6457-6459
Number of pages	3
Journal	Tetrahedron Letters
Volume	52
Issue number	48
DOIs	https://doi.org/10.1016/j.tetlet.2011.09.100
State	Published - 30 Nov 2011
Externally published	Yes

Keywords

Lipophilicity
LogD
Ring closing metathesis
Spiropiperidine

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10.1016/j.tetlet.2011.09.100

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@article{080eb9888f3040999055c4a81916a586,

title = "Synthesis of oxaspiropiperidines as a strategy for lowering logD",

abstract = "The syntheses of four new spiropiperidines designed as polar analogs of methyl 2-(3-azaspiro[5.5]undec-an-9-yl)acetate are described.",

keywords = "Lipophilicity, LogD, Ring closing metathesis, Spiropiperidine",

author = "Timothy Cernak and Kevin Dykstra and Dorothy Levorse and Andreas Verras and James Balkovec and Ravi Nargund and Robert DeVita",

year = "2011",

month = nov,

day = "30",

doi = "10.1016/j.tetlet.2011.09.100",

language = "English",

volume = "52",

pages = "6457--6459",

journal = "Tetrahedron Letters",

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publisher = "Elsevier Ltd.",

number = "48",

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TY - JOUR

T1 - Synthesis of oxaspiropiperidines as a strategy for lowering logD

AU - Cernak, Timothy

AU - Dykstra, Kevin

AU - Levorse, Dorothy

AU - Verras, Andreas

AU - Balkovec, James

AU - Nargund, Ravi

AU - DeVita, Robert

PY - 2011/11/30

Y1 - 2011/11/30

N2 - The syntheses of four new spiropiperidines designed as polar analogs of methyl 2-(3-azaspiro[5.5]undec-an-9-yl)acetate are described.

AB - The syntheses of four new spiropiperidines designed as polar analogs of methyl 2-(3-azaspiro[5.5]undec-an-9-yl)acetate are described.

KW - Lipophilicity

KW - LogD

KW - Ring closing metathesis

KW - Spiropiperidine

UR - https://www.scopus.com/pages/publications/80255127533

U2 - 10.1016/j.tetlet.2011.09.100

DO - 10.1016/j.tetlet.2011.09.100

M3 - Article

AN - SCOPUS:80255127533

SN - 0040-4039

VL - 52

SP - 6457

EP - 6459

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 48

ER -

Synthesis of oxaspiropiperidines as a strategy for lowering logD

Abstract

Keywords

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