Synthesis of oxaspiropiperidines as a strategy for lowering logD

Timothy Cernak, Kevin Dykstra, Dorothy Levorse, Andreas Verras, James Balkovec, Ravi Nargund, Robert DeVita

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The syntheses of four new spiropiperidines designed as polar analogs of methyl 2-(3-azaspiro[5.5]undec-an-9-yl)acetate are described.

Original languageEnglish
Pages (from-to)6457-6459
Number of pages3
JournalTetrahedron Letters
Volume52
Issue number48
DOIs
StatePublished - 30 Nov 2011
Externally publishedYes

Keywords

  • Lipophilicity
  • LogD
  • Ring closing metathesis
  • Spiropiperidine

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