Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells

Olesya D. Fedoryak; Jai Yoon Sul; Philip G. Haydon; Graham C.R. Ellis-Davies

doi:10.1039/b504922a

Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells

Olesya D. Fedoryak, Jai Yoon Sul, Philip G. Haydon, Graham C.R. Ellis-Davies

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57 Scopus citations

Abstract

We have synthesized a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate (which we call MDNI-glu) that makes more efficient use of incident light than all other caged glutamates. Laser flash photolysis of MDNI-glu in acutely isolated hippocampal brain slices evoked a rapid increase in intracellular Ca²⁺ concentration in astrocytes.

Original language	English
Pages (from-to)	3664-3666
Number of pages	3
Journal	Chemical Communications
Issue number	29
DOIs	https://doi.org/10.1039/b504922a
State	Published - 7 Aug 2005
Externally published	Yes

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title = "Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells",

abstract = "We have synthesized a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate (which we call MDNI-glu) that makes more efficient use of incident light than all other caged glutamates. Laser flash photolysis of MDNI-glu in acutely isolated hippocampal brain slices evoked a rapid increase in intracellular Ca2+ concentration in astrocytes.",

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AU - Ellis-Davies, Graham C.R.

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AB - We have synthesized a biologically inert, photosensitive derivative of the major excitatory amino acid, L-glutamate (which we call MDNI-glu) that makes more efficient use of incident light than all other caged glutamates. Laser flash photolysis of MDNI-glu in acutely isolated hippocampal brain slices evoked a rapid increase in intracellular Ca2+ concentration in astrocytes.

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JO - Chemical Communications

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Synthesis of a caged glutamate for efficient one- and two-photon photorelease on living cells

Abstract

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