Synthesis of a C-glycoside analogue of sTn: An HIV- and tumor-associated antigen

Balagurunathan Kuberan; Sulthan A. Sikkander; Hiroshi Tomiyama; Robert J. Linhardt

doi:10.1002/anie.200351099

Synthesis of a C-glycoside analogue of sTn: An HIV- and tumor-associated antigen

Balagurunathan Kuberan, Sulthan A. Sikkander, Hiroshi Tomiyama, Robert J. Linhardt

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

The nonhydrolyzable glycosidic linkage to sialic acid in the C-glycoside analogue of sTn, 1, is the key feature of the redesigned glycoconjugate. This potential antitumor and anti-HIV agent was prepared in one enzymatic and seventeen chemical steps starting from diisopropylidene galactopyranose.

Original language	English
Pages (from-to)	2073-2075
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	18
DOIs	https://doi.org/10.1002/anie.200351099
State	Published - 9 May 2003
Externally published	Yes

Keywords

Anti-HIV agents
Antitumor agents
C-glycosides
Glycopeptides
Sialic acid

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10.1002/anie.200351099

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AU - Linhardt, Robert J.

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KW - Glycopeptides

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Synthesis of a C-glycoside analogue of sTn: An HIV- and tumor-associated antigen

Abstract

Keywords

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