Synthesis of 4-Trifluoromethylated 2-Alkyl- and 2,3-Dialkyl-Substituted Azetidines

Jinlong Jiang; Hemal Shah; Robert J. DeVita

doi:10.1021/ol030099p

Synthesis of 4-Trifluoromethylated 2-Alkyl- and 2,3-Dialkyl-Substituted Azetidines

Jinlong Jiang, Hemal Shah, Robert J. DeVita

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Abstract

(Equation presented) A diastereoselective approach to the synthesis of 4-trifluoromethylated 2-alkyl- and 2,3-dialkylazetidines, including BOC-protected 4-trifluoromethylazetidin-2-ylcarboxylic acid, was developed via Wittig reaction of 4-trifluomethylated β-lactam followed by alkylation and hydrogenation.

Original language	English
Pages (from-to)	4101-4103
Number of pages	3
Journal	Organic Letters
Volume	5
Issue number	22
DOIs	https://doi.org/10.1021/ol030099p
State	Published - 30 Oct 2003
Externally published	Yes

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title = "Synthesis of 4-Trifluoromethylated 2-Alkyl- and 2,3-Dialkyl-Substituted Azetidines",

abstract = "(Equation presented) A diastereoselective approach to the synthesis of 4-trifluoromethylated 2-alkyl- and 2,3-dialkylazetidines, including BOC-protected 4-trifluoromethylazetidin-2-ylcarboxylic acid, was developed via Wittig reaction of 4-trifluomethylated β-lactam followed by alkylation and hydrogenation.",

author = "Jinlong Jiang and Hemal Shah and DeVita, {Robert J.}",

year = "2003",

month = oct,

day = "30",

doi = "10.1021/ol030099p",

language = "English",

volume = "5",

pages = "4101--4103",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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T1 - Synthesis of 4-Trifluoromethylated 2-Alkyl- and 2,3-Dialkyl-Substituted Azetidines

AU - Jiang, Jinlong

AU - Shah, Hemal

AU - DeVita, Robert J.

PY - 2003/10/30

Y1 - 2003/10/30

N2 - (Equation presented) A diastereoselective approach to the synthesis of 4-trifluoromethylated 2-alkyl- and 2,3-dialkylazetidines, including BOC-protected 4-trifluoromethylazetidin-2-ylcarboxylic acid, was developed via Wittig reaction of 4-trifluomethylated β-lactam followed by alkylation and hydrogenation.

AB - (Equation presented) A diastereoselective approach to the synthesis of 4-trifluoromethylated 2-alkyl- and 2,3-dialkylazetidines, including BOC-protected 4-trifluoromethylazetidin-2-ylcarboxylic acid, was developed via Wittig reaction of 4-trifluomethylated β-lactam followed by alkylation and hydrogenation.

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U2 - 10.1021/ol030099p

DO - 10.1021/ol030099p

M3 - Article

AN - SCOPUS:0344082900

SN - 1523-7060

VL - 5

SP - 4101

EP - 4103

JO - Organic Letters

JF - Organic Letters

IS - 22

ER -

Synthesis of 4-Trifluoromethylated 2-Alkyl- and 2,3-Dialkyl-Substituted Azetidines

Abstract

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