Synthesis of 3-Azabicyclo[3.3.0]octane Framework and a Novel Tricyclicaminoether

H. Ümit Kaniskan, Özdemir Dogan

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The efficient synthesis of 3-azabicyclo [3.3.0]octane derivative 1 and a novel tricyclicaminoether 11 has been achieved in seven steps using commercially available starting materials and commonly used reagents. The key steps are the intramolecular ring opening of epoxide 7 providing tricyclic aminoalcohol 3 and Baeyer-Villiger oxidation of ketone 8 providing the corresponding lactone 2. Both reactions proceeded regiospecifically.

Original languageEnglish
Pages (from-to)3833-3841
Number of pages9
JournalSynthetic Communications
Issue number21
StatePublished - 2003
Externally publishedYes


  • Baeyer-Villiger oxidation
  • Cage-like oxaheterocycle
  • Intramolecular cyclization
  • Tricyclicaminoether


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