Abstract
Indapamide (IV) was prepared by four step reactions, starting from 4- chloro-3-sulphamoyl-benzoic acid, l-amino-2, 3-dihydro-2-methyl-lH-indole and hydroxylamine-O-sulphonic acid. 4-chloro-3-sulphamoyl-benzoyl chloride ( I ) was prepared by the reaction of 4-chloro-3-sulphamoyl-benzoic acid and thionyl chloride, yield 97. 4%. Hydroxylamine-O-sulphonic acid( II ) was prepared by the reaction of hydroxylamine with 25% oleum, yield 94.7%. l-amino-2, 3-dihydro-2-methyl-lH- indole hydrochloride(III ) was obtained by the reaction of 2, 3-dihydro-2-methyl-lH- indole with II, yield 81. 7%. III was reacted with I to give the title compound IV, yield 77, 4%. Methods of purification of III and IV were also described.
| Original language | English |
|---|---|
| Pages (from-to) | 531-534 |
| Number of pages | 4 |
| Journal | Beijing Ligong Daxue Xuebao/Transaction of Beijing Institute of Technology |
| Volume | 21 |
| Issue number | 4 |
| State | Published - 2001 |
| Externally published | Yes |
Keywords
- Indapamide
- Preparation
- Purification