Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine

Yuko Murakami; Rina Suzuki; Hiroto Yanuma; Jiangtao He; Shuren Ma; Gerard M. Turino; Yong Y. Lin; Toyonobu Usuki

doi:10.1039/c4ob01438c

Synthesis and LC-MS/MS analysis of desmosine-CH₂, a potential internal standard for the degraded elastin biomarker desmosine

Yuko Murakami, Rina Suzuki, Hiroto Yanuma, Jiangtao He, Shuren Ma, Gerard M. Turino, Yong Y. Lin, Toyonobu Usuki

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Desmosine-CH₂, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH₂ was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH₂ was also achieved.

Original language	English
Pages (from-to)	9887-9894
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	12
Issue number	48
DOIs	https://doi.org/10.1039/c4ob01438c
State	Published - 28 Dec 2014
Externally published	Yes

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title = "Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine",

abstract = "Desmosine-CH2, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH2 was completed in 22\% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH2 was also achieved.",

author = "Yuko Murakami and Rina Suzuki and Hiroto Yanuma and Jiangtao He and Shuren Ma and Turino, \{Gerard M.\} and Lin, \{Yong Y.\} and Toyonobu Usuki",

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AU - Murakami, Yuko

AU - Suzuki, Rina

AU - Yanuma, Hiroto

AU - He, Jiangtao

AU - Ma, Shuren

AU - Turino, Gerard M.

AU - Lin, Yong Y.

AU - Usuki, Toyonobu

PY - 2014/12/28

Y1 - 2014/12/28

N2 - Desmosine-CH2, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH2 was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH2 was also achieved.

AB - Desmosine-CH2, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH2 was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH2 was also achieved.

UR - https://www.scopus.com/pages/publications/84911921368

U2 - 10.1039/c4ob01438c

DO - 10.1039/c4ob01438c

M3 - Article

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AN - SCOPUS:84911921368

SN - 1477-0520

VL - 12

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EP - 9894

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 48

ER -

Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine

Abstract

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Synthesis and LC-MS/MS analysis of desmosine-CH₂, a potential internal standard for the degraded elastin biomarker desmosine