Abstract
Desmosine-CH2, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH2 was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH2 was also achieved.
Original language | English |
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Pages (from-to) | 9887-9894 |
Number of pages | 8 |
Journal | Organic and Biomolecular Chemistry |
Volume | 12 |
Issue number | 48 |
DOIs | |
State | Published - 28 Dec 2014 |
Externally published | Yes |