Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosine

Yuko Murakami, Rina Suzuki, Hiroto Yanuma, Jiangtao He, Shuren Ma, Gerard M. Turino, Yong Y. Lin, Toyonobu Usuki

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Desmosine-CH2, an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH2 was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH2 was also achieved.

Original languageEnglish
Pages (from-to)9887-9894
Number of pages8
JournalOrganic and Biomolecular Chemistry
Volume12
Issue number48
DOIs
StatePublished - 28 Dec 2014
Externally publishedYes

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