Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

Anita Gianella; Aneta J. Mieszawska; Freek J.M. Hoeben; Henk M. Janssen; Peter A. Jarzyna; David P. Cormode; Kevin D. Costa; Satish Rao; Omid C. Farokhzad; Robert Langer; Zahi A. Fayad; Willem J.M. Mulder

doi:10.1039/c3cc43618g

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

Anita Gianella, Aneta J. Mieszawska, Freek J.M. Hoeben, Henk M. Janssen, Peter A. Jarzyna, David P. Cormode, Kevin D. Costa, Satish Rao, Omid C. Farokhzad, Robert Langer, Zahi A. Fayad, Willem J.M. Mulder

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15 Scopus citations

Abstract

We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.

Original language	English
Pages (from-to)	9392-9394
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	82
DOIs	https://doi.org/10.1039/c3cc43618g
State	Published - 19 Sep 2013

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Gianella, A., Mieszawska, A. J., Hoeben, F. J. M., Janssen, H. M., Jarzyna, P. A., Cormode, D. P., Costa, K. D., Rao, S., Farokhzad, O. C., Langer, R., Fayad, Z. A., & Mulder, W. J. M. (2013). Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform. Chemical Communications, 49(82), 9392-9394. https://doi.org/10.1039/c3cc43618g

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abstract = "We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.",

author = "Anita Gianella and Mieszawska, {Aneta J.} and Hoeben, {Freek J.M.} and Janssen, {Henk M.} and Jarzyna, {Peter A.} and Cormode, {David P.} and Costa, {Kevin D.} and Satish Rao and Farokhzad, {Omid C.} and Robert Langer and Fayad, {Zahi A.} and Mulder, {Willem J.M.}",

year = "2013",

month = sep,

day = "19",

doi = "10.1039/c3cc43618g",

language = "English",

volume = "49",

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journal = "Chemical Communications",

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T1 - Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

AU - Gianella, Anita

AU - Mieszawska, Aneta J.

AU - Hoeben, Freek J.M.

AU - Janssen, Henk M.

AU - Jarzyna, Peter A.

AU - Cormode, David P.

AU - Costa, Kevin D.

AU - Rao, Satish

AU - Farokhzad, Omid C.

AU - Langer, Robert

AU - Fayad, Zahi A.

AU - Mulder, Willem J.M.

PY - 2013/9/19

Y1 - 2013/9/19

N2 - We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.

AB - We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated in vitro using biotin and αvβ3-integrin-specific RGD-peptide functionalized nanoparticles.

UR - http://www.scopus.com/inward/record.url?scp=84884523120&partnerID=8YFLogxK

U2 - 10.1039/c3cc43618g

DO - 10.1039/c3cc43618g

M3 - Article

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AN - SCOPUS:84884523120

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VL - 49

SP - 9392

EP - 9394

JO - Chemical Communications

JF - Chemical Communications

IS - 82

ER -

Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

Abstract

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