Synthesis and evaluation of 1-[11C]methyl-4-aryl-piperazinium salts as myocardial imaging agents

D. R. Elmaleh; S. Padmanabhan; M. A. Hassan; J. A. Correia; L. W. Herman; R. N. Hanson; H. W. Strauss

doi:10.1016/0969-8051(93)90073-4

Synthesis and evaluation of 1-[¹¹C]methyl-4-aryl-piperazinium salts as myocardial imaging agents

D. R. Elmaleh, S. Padmanabhan, M. A. Hassan, J. A. Correia, L. W. Herman, R. N. Hanson, H. W. Strauss

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Our previous study with radioiodinated 1-methyl-1-(2-hydroxyethyl)-4-phenylpiperazinium derivatives indicated that these compounds localize selectively in the rat myocardium. Based upon these results, 1-[¹¹C]methyl-1-alkyl-4-phenylpiperazinium cations were synthesized and evaluated for their potential as myocardial imaging agents. Biodistribution studies were performed in rats and imaging studies in normal dogs. The results indicate high concentrations of 3-4% ID/g in the rat heart at 5 min, comparable to those obtained with the radioiodinated analogs. Sequential imaging of the canine heart showed a similar pattern of uptake. The level of activity reached at 20 min was maintained over the 1-h time period. These results suggest that the phenylpiperazinium agents may have potential application as myocardial imaging agents.

Original language	English
Pages (from-to)	427-433
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	20
Issue number	4
DOIs	https://doi.org/10.1016/0969-8051(93)90073-4
State	Published - May 1993
Externally published	Yes

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title = "Synthesis and evaluation of 1-[11C]methyl-4-aryl-piperazinium salts as myocardial imaging agents",

abstract = "Our previous study with radioiodinated 1-methyl-1-(2-hydroxyethyl)-4-phenylpiperazinium derivatives indicated that these compounds localize selectively in the rat myocardium. Based upon these results, 1-[11C]methyl-1-alkyl-4-phenylpiperazinium cations were synthesized and evaluated for their potential as myocardial imaging agents. Biodistribution studies were performed in rats and imaging studies in normal dogs. The results indicate high concentrations of 3-4\% ID/g in the rat heart at 5 min, comparable to those obtained with the radioiodinated analogs. Sequential imaging of the canine heart showed a similar pattern of uptake. The level of activity reached at 20 min was maintained over the 1-h time period. These results suggest that the phenylpiperazinium agents may have potential application as myocardial imaging agents.",

author = "Elmaleh, \{D. R.\} and S. Padmanabhan and Hassan, \{M. A.\} and Correia, \{J. A.\} and Herman, \{L. W.\} and Hanson, \{R. N.\} and Strauss, \{H. W.\}",

year = "1993",

month = may,

doi = "10.1016/0969-8051(93)90073-4",

language = "English",

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pages = "427--433",

journal = "Nuclear Medicine and Biology",

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TY - JOUR

T1 - Synthesis and evaluation of 1-[11C]methyl-4-aryl-piperazinium salts as myocardial imaging agents

AU - Elmaleh, D. R.

AU - Padmanabhan, S.

AU - Hassan, M. A.

AU - Correia, J. A.

AU - Herman, L. W.

AU - Hanson, R. N.

AU - Strauss, H. W.

PY - 1993/5

Y1 - 1993/5

N2 - Our previous study with radioiodinated 1-methyl-1-(2-hydroxyethyl)-4-phenylpiperazinium derivatives indicated that these compounds localize selectively in the rat myocardium. Based upon these results, 1-[11C]methyl-1-alkyl-4-phenylpiperazinium cations were synthesized and evaluated for their potential as myocardial imaging agents. Biodistribution studies were performed in rats and imaging studies in normal dogs. The results indicate high concentrations of 3-4% ID/g in the rat heart at 5 min, comparable to those obtained with the radioiodinated analogs. Sequential imaging of the canine heart showed a similar pattern of uptake. The level of activity reached at 20 min was maintained over the 1-h time period. These results suggest that the phenylpiperazinium agents may have potential application as myocardial imaging agents.

AB - Our previous study with radioiodinated 1-methyl-1-(2-hydroxyethyl)-4-phenylpiperazinium derivatives indicated that these compounds localize selectively in the rat myocardium. Based upon these results, 1-[11C]methyl-1-alkyl-4-phenylpiperazinium cations were synthesized and evaluated for their potential as myocardial imaging agents. Biodistribution studies were performed in rats and imaging studies in normal dogs. The results indicate high concentrations of 3-4% ID/g in the rat heart at 5 min, comparable to those obtained with the radioiodinated analogs. Sequential imaging of the canine heart showed a similar pattern of uptake. The level of activity reached at 20 min was maintained over the 1-h time period. These results suggest that the phenylpiperazinium agents may have potential application as myocardial imaging agents.

UR - https://www.scopus.com/pages/publications/0027212325

U2 - 10.1016/0969-8051(93)90073-4

DO - 10.1016/0969-8051(93)90073-4

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AN - SCOPUS:0027212325

SN - 0969-8051

VL - 20

SP - 427

EP - 433

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

IS - 4

ER -

Synthesis and evaluation of 1-[11C]methyl-4-aryl-piperazinium salts as myocardial imaging agents

Abstract

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Synthesis and evaluation of 1-[¹¹C]methyl-4-aryl-piperazinium salts as myocardial imaging agents