Synthesis and biological evaluation of flavonol-glucose conjugates for cosmeceutical development

Kwang Su Park, Hyungmi Kim, Mi Kyoung Kim, Kyungdo Kim, Youhoon Chong

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Quercetin and kaempferol, two well-known flavonols, were chemically conjugated with glucose to produce the corresponding flavonol glucosides, and the following biological activities were evaluated for cosmeceutical development: antioxidant activity, ability to increase collagen synthesis, and moisturizing activity. Among the synthetic flavonol glucosides, quercetin-3-O-β-D-glucoside significantly enhanced collagen synthesis (60 %) compared to quercetin. Kaempferol-3,7-di-O-β-D-glucoside showed promising skin-moisturizing effects, inducing a sixfold increase in the expression of aquaporin-3. Thus, both quercetin-3-O-β-D-glucoside and kaempferol-3,7-di-O-β-D-glucoside were shown to possess interesting biological activities which warrant their further development as cosmetic ingredients.

Original languageEnglish
Pages (from-to)317-323
Number of pages7
JournalJournal of the Korean Society for Applied Biological Chemistry
Volume58
Issue number3
DOIs
StatePublished - 1 Jun 2015
Externally publishedYes

Keywords

  • Aquaporin-3
  • Collagen synthesis
  • Cosmetic ingredient
  • Kaempferol glucoside
  • Quercetin glucoside

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