Synthesis and bioassay of amino-pyrazolone, amino-isoxazolone and amino-pyrimidinone derivatives

Venkatapuram Padmavathi, Dandu Rangayapalle Chinna Venkata Subbaiah, Konda Mahesh, Thunga Radha Lakshmi

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Novel amino-pyrazolone, amino-isoxazolone and amino-pyrimidinone derivatives were prepared from ethyl 4-phenylsulfonyl-2-(2′- phenylsulfonylethyl)-2-cyanobutyrate (1), ethyl 4-arylsulfonyl-3-aryl-2- cyanobutyrate (7) and ethyl 4-arylmethylsulfonyl-3-aryl-2-cyanobutyrate (8). The lead molecules have been tested for their antimicrobial activity and antioxidant property.

Original languageEnglish
Pages (from-to)1704-1709
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number12
DOIs
StatePublished - Dec 2007
Externally publishedYes

Keywords

  • Amino-isoxazolone
  • Amino-pyrazolone
  • Amino-pyrimidinone
  • Antimicrobial activity
  • Antioxidant property

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