Synthesis and antiviral activity of some fluorinated nucleotide derivatives

Natalia Dyatkina; Audrey Arzumanov; Alexander Krayevsky; Bryan O'Hara; Yacov Gluzman; Penny Baron; Clarinda Maclow; Bruce Polsky

doi:10.1080/15257779408013244

Synthesis and antiviral activity of some fluorinated nucleotide derivatives

Natalia Dyatkina
, Audrey Arzumanov
, Alexander Krayevsky
, Bryan O'Hara
, Yacov Gluzman
, Penny Baron
, Clarinda Maclow
, Bruce Polsky

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A number of 3’-fluoro-3’-deoxythyinidine 5’-phosphonates and nucleoside 5’-phosphorofluoridates were prepared to study their ability to inhibit replication of HIV-1. Compounds, the 5’-phosphorofluoridates of 3'-azido-3’-deoxythymidine (VIIIc). 3’fluoro-3’-deoxythyinidine (VIIId) and 3'-deoxy-2^,,3’-didehydrothymidine (VIIIe), exhibit potent anti-HIV-1 activities.

Original language	English
Pages (from-to)	325-337
Number of pages	13
Journal	Nucleosides and Nucleotides
Volume	13
Issue number	1-3
DOIs	https://doi.org/10.1080/15257779408013244
State	Published - 1 Mar 1994
Externally published	Yes

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title = "Synthesis and antiviral activity of some fluorinated nucleotide derivatives",

abstract = "A number of 3{\textquoteright}-fluoro-3{\textquoteright}-deoxythyinidine 5{\textquoteright}-phosphonates and nucleoside 5{\textquoteright}-phosphorofluoridates were prepared to study their ability to inhibit replication of HIV-1. Compounds, the 5{\textquoteright}-phosphorofluoridates of 3'-azido-3{\textquoteright}-deoxythymidine (VIIIc). 3{\textquoteright}fluoro-3{\textquoteright}-deoxythyinidine (VIIId) and 3'-deoxy-2,,3{\textquoteright}-didehydrothymidine (VIIIe), exhibit potent anti-HIV-1 activities.",

author = "Natalia Dyatkina and Audrey Arzumanov and Alexander Krayevsky and Bryan O'Hara and Yacov Gluzman and Penny Baron and Clarinda Maclow and Bruce Polsky",

note = "Funding Information: Acknowledgment This iiivestigatioii was supported by grants from Russian State A1 DS Program (grants SP 306, 35 1) aiid American Cyaiiaiiiid Company.",

year = "1994",

month = mar,

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doi = "10.1080/15257779408013244",

language = "English",

volume = "13",

pages = "325--337",

journal = "Nucleosides and Nucleotides",

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T1 - Synthesis and antiviral activity of some fluorinated nucleotide derivatives

AU - Dyatkina, Natalia

AU - Arzumanov, Audrey

AU - Krayevsky, Alexander

AU - O'Hara, Bryan

AU - Gluzman, Yacov

AU - Baron, Penny

AU - Maclow, Clarinda

AU - Polsky, Bruce

N1 - Funding Information: Acknowledgment This iiivestigatioii was supported by grants from Russian State A1 DS Program (grants SP 306, 35 1) aiid American Cyaiiaiiiid Company.

PY - 1994/3/1

Y1 - 1994/3/1

N2 - A number of 3’-fluoro-3’-deoxythyinidine 5’-phosphonates and nucleoside 5’-phosphorofluoridates were prepared to study their ability to inhibit replication of HIV-1. Compounds, the 5’-phosphorofluoridates of 3'-azido-3’-deoxythymidine (VIIIc). 3’fluoro-3’-deoxythyinidine (VIIId) and 3'-deoxy-2,,3’-didehydrothymidine (VIIIe), exhibit potent anti-HIV-1 activities.

AB - A number of 3’-fluoro-3’-deoxythyinidine 5’-phosphonates and nucleoside 5’-phosphorofluoridates were prepared to study their ability to inhibit replication of HIV-1. Compounds, the 5’-phosphorofluoridates of 3'-azido-3’-deoxythymidine (VIIIc). 3’fluoro-3’-deoxythyinidine (VIIId) and 3'-deoxy-2,,3’-didehydrothymidine (VIIIe), exhibit potent anti-HIV-1 activities.

UR - https://www.scopus.com/pages/publications/0028354166

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DO - 10.1080/15257779408013244

M3 - Article

AN - SCOPUS:0028354166

SN - 0732-8311

VL - 13

SP - 325

EP - 337

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

IS - 1-3

ER -

Synthesis and antiviral activity of some fluorinated nucleotide derivatives

Abstract

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