Synthesis and antiviral activity of some fluorinated nucleotide derivatives

Natalia Dyatkina, Audrey Arzumanov, Alexander Krayevsky, Bryan O'Hara, Yacov Gluzman, Penny Baron, Clarinda Maclow, Bruce Polsky

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

A number of 3’-fluoro-3’-deoxythyinidine 5’-phosphonates and nucleoside 5’-phosphorofluoridates were prepared to study their ability to inhibit replication of HIV-1. Compounds, the 5’-phosphorofluoridates of 3'-azido-3’-deoxythymidine (VIIIc). 3’fluoro-3’-deoxythyinidine (VIIId) and 3'-deoxy-2,,3’-didehydrothymidine (VIIIe), exhibit potent anti-HIV-1 activities.

Original languageEnglish
Pages (from-to)325-337
Number of pages13
JournalNucleosides and Nucleotides
Volume13
Issue number1-3
DOIs
StatePublished - 1 Mar 1994
Externally publishedYes

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