Synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome treated with a combination of isotretinoin and pamidronate

Hassan Galadari, Alyssa G. Bishop, Suraj S. Venna, Emad Sultan, Daihung Do, Ross Zeltser

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a clinically heterogeneous entity, encompassing a variety of debilitating conditions that have in common inflammation of the skeletal system and skin. To date, there is a paucity of documented efficacious treatment options. We report a 48-year-old man with skeletal and cutaneous signs and symptoms who improved dramatically after treatment with a combination of isotretinoin and pamidronate. This report provides an alternative treatment regimen for SAPHO that addresses the possible underlying pathophysiology of this likely underdiagnosed syndrome.

Original languageEnglish
Pages (from-to)123-125
Number of pages3
JournalJournal of the American Academy of Dermatology
Volume61
Issue number1
DOIs
StatePublished - Jul 2009
Externally publishedYes

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