Synovial inflammation in patients with osteonecrosis of the femoral head

Bradley J. Rabquer, Giselle J. Tan, Philip J. Shaheen, G. Kenneth Haines, Andrew G. Urquhart, Alisa E. Koch

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Much of the work aimed at elucidating the pathogenesis of osteonecrosis (ON) of the femoral head has focused on bone blood supply, with little attention to the surrounding synovial tissue (ST). We hypothesized that patients with ON exhibit synovial inflammation. Using immunohistological techniques, we found that a large population of patients with ON had synovial inflammation. Moreover, a population of ON patients had inflamed ST without having an inflammatory disease co-morbidity. The inflammatory infiltrate in these patients comprised primarily CD4+ T cells and CD68+ macrophages, the latter of which expressed increased levels of cellular adhesion molecules. Our results suggest the presence of a previously unrecognized population of ON patients without a diagnosed inflammatory co-morbidity and a highly inflammed synovium consisting primarily of a macrophage and CD4+ T-cell infi ltrate.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalClinical and Translational Science
Volume2
Issue number4
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Adhesion molecules
  • Inflammation
  • Macrophage
  • Osteonecrosis
  • Synovium

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