Synergistic targeting of α vβ 3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis

Ewelina Kluza, Daisy W.J. Van Der Schaft, Petra A.I. Hautvast, Willem J.M. Mulder, Kevin H. Mayo, Arjan W. Griffioen, Gustav J. Strijkers, Klaas Nicolay

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

Effective and specific targeting of nanoparticles is of paramount importance in the fields of targeted therapeutics and diagnostics. In the current study, we investigated the targeting efficacy of nanoparticles that were functionalized with two angiogenesis-specific targeting ligands, an α vβ 3 integrin-specific and a galectin-1-specific peptide. We show in vitro, using optical techniques and MRI, that the dual-targeting approach produces synergistic targeting effects, causing a dramatically elevated uptake of nanoparticles as compared to single ligand targeting.

Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalNano Letters
Volume10
Issue number1
DOIs
StatePublished - 13 Jan 2010

Keywords

  • Angiogenesis
  • Anti-angiogenic therapy
  • Magnetic resonance imaging
  • Molecular imaging
  • Synergistic targeting

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