Syncope after COVID-19 Vaccination in a Young Man with Unmasking Brugada Syndrome

Takafumi Okuyama, Tomoyuki Kabutoya, Yuki Gonda, Kana Kubota Kashihara, Yasushi Imai, Yuji Morisawa, Kazuomi Kario

Research output: Contribution to journalArticlepeer-review


A 23-year-old man with no significant medical history was rushed to a hospital due to transient loss of consciousness with incontinence. The patient had developed a fever after his second dose of coronavirus disease 2019 (COVID-19) vaccine, and the patient was found groaning in bed approximately 40 hours after the vaccination in the early morning. The patient was diagnosed with Brugada syndrome (BrS) based on a drug-provocation test. His father had been diagnosed with BrS and died suddenly at 51 years of age. Young adults with a family history of BrS should be cautioned about fever following COVID-19 vaccination.

Original languageEnglish
Pages (from-to)1191-1194
Number of pages4
JournalInternal Medicine
Issue number8
StatePublished - 2023
Externally publishedYes


  • electrocardiography
  • electrophysiological examination
  • fever
  • ventricular fibrillation


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