Synaptic tagging during memory allocation

Thomas Rogerson, Denise J. Cai, Adam Frank, Yoshitake Sano, Justin Shobe, Manuel F. Lopez-Aranda, Alcino J. Silva

Research output: Contribution to journalReview articlepeer-review

181 Scopus citations

Abstract

There is now compelling evidence that the allocation of memory to specific neurons (neuronal allocation) and synapses (synaptic allocation) in a neurocircuit is not random and that instead specific mechanisms, such as increases in neuronal excitability and synaptic tagging and capture, determine the exact sites where memories are stored. We propose an integrated view of these processes, such that neuronal allocation, synaptic tagging and capture, spine clustering and metaplasticity reflect related aspects of memory allocation mechanisms. Importantly, the properties of these mechanisms suggest a set of rules that profoundly affect how memories are stored and recalled.

Original languageEnglish
Pages (from-to)157-169
Number of pages13
JournalNature Reviews Neuroscience
Volume15
Issue number3
DOIs
StatePublished - Mar 2014
Externally publishedYes

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