Swine Model of Myocardial Infarction Induced by Ischemia-Reperfusion and Embolization

Renata Mazurek, Olympia Bikou, Kiyotake Ishikawa

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Acute myocardial infarction continues to account for a growing burden of heart failure worldwide. Despite existing therapies, new approaches for reducing the extent of damage and better managing heart failure progression are urgently needed. Preclinical large animal models are a critical step in the translation of scientific discoveries toward clinical trials and therapeutic application. In this chapter, we detail methods to induce swine models of myocardial infarction through catheter-mediated approaches involving either temporary (ischemia-reperfusion) or permanent (thrombus injection or embolic coil) occlusions. These techniques are relatively low in invasiveness, while infarct size with corresponding cardiac dysfunction can be controlled by adjusting the location of coronary occlusion. We also describe methods for cardiac angiography and echocardiography in pigs. This is the second edition of a previously published chapter with modifications.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages189-203
Number of pages15
DOIs
StatePublished - 2024

Publication series

NameMethods in Molecular Biology
Volume2803
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Coil embolization
  • Coronary angiography
  • Coronary microembolization
  • Ischemia-reperfusion
  • Myocardial infarction
  • No-reflow
  • Pig model
  • Thrombotic MI
  • Thrombus injection
  • Transmural infarction

Fingerprint

Dive into the research topics of 'Swine Model of Myocardial Infarction Induced by Ischemia-Reperfusion and Embolization'. Together they form a unique fingerprint.

Cite this