Sweet dreams: glycosylation controls tumor cell dormancy

Research output: Contribution to journalShort surveypeer-review

Abstract

In a recent study in Cancer Cell, Sreekumar et al. used therapy-associated breast cancer mouse models as well as in vitro dormancy models to identify extracellular matrix (ECM)-related tumor cell-autonomous mechanisms of dormancy in residual tumor cells (RTCs). The study reveals an important role of the glycosylation of proteoglycans in sustaining dormancy and opens the door to leverage this biology to eliminate RTCs and prevent recurrence.

Original languageEnglish
Pages (from-to)180-181
Number of pages2
JournalTrends in Cancer
Volume10
Issue number3
DOIs
StatePublished - Mar 2024

Keywords

  • dormancy
  • extracellular matrix
  • glycosylation
  • metastasis

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