Sustained induction of egr-1 by v-src correlates with a lack of Fos-mediated repression of the egr-1 promoter

S. A. Qureshi, M. Rim, K. Alexandropoulos, K. Berg, V. P. Sukhatme, D. A. Foster

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9 Scopus citations

Abstract

Serum stimulation of quiescent fibroblasts leads to a transient induction of the transcription factor egr-1. However, the induction of egr-1 by v-src was found to be sustained rather than transient. The proto-oncogene fos has been reported to be co-regulated with egr-1 and to repress serum-induced egr-1 expression. We found that c-fos prevents v-src-induced gene expression regulated by the egr-1 promoter. Thus, the sustained induction of egr-1 by v-src could be explained by a lack of c-fos induction by v-src. Consistent with this hypothesis, egr-1 and c-fos were co-induced by serum, but not by v-src, in Balb/c 3T3 cells; v-src did not induce c-Sos expression in these cells. We propose that sustained expression of egr-1 induced by v-src in Balb/c 3T3 cells is due to a lack of c-fos down-regulation of egr-1.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalOncogene
Volume7
Issue number1
StatePublished - 1992
Externally publishedYes

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