Sustained Activation of AMPK Enhances Differentiation of Human iPSC-Derived Cardiomyocytes via Sirtuin Activation

Mohsen Sarikhani, Jessica C. Garbern, Sai Ma, Rebecca Sereda, Jeffrey Conde, Guido Krähenbühl, Gabriela O. Escalante, Aishah Ahmed, Jason D. Buenrostro, Richard T. Lee

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Lee and colleagues demonstrate that sustained activation of AMPK enhances differentiation of iPSC-derived cardiomyocytes. Sustained AMPK activation decreased histone acetylation at known target sites for nuclear-localized sirtuins, suggesting that AMPK activation enhances sirtuin activity. AMPK-induced sirtuin-mediated deacetylation of histone proteins may regulate chromatin accessibility and enhance cardiomyocyte differentiation.

Original languageEnglish
Pages (from-to)498-514
Number of pages17
JournalStem Cell Reports
Volume15
Issue number2
DOIs
StatePublished - 11 Aug 2020
Externally publishedYes

Keywords

  • AMPK
  • histone acetylation
  • iPSC-derived cardiomyocytes
  • sirtuin

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