Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry

Orna Levran; Einat Peles; Matthew Randesi; Joel Correa Da Rosa; Jurg Ott; John Rotrosen; Miriam Adelson; Mary Jeanne Kreek

doi:10.2217/pgs.15.86

Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry

Orna Levran
, Einat Peles
, Matthew Randesi
, Joel Correa Da Rosa
, Jurg Ott
, John Rotrosen
, Miriam Adelson
, Mary Jeanne Kreek

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Background: Drug addiction is influenced by genetic factors. Aim: To determine if genetic variants in the serotonergic and adrenergic pathways are associated with heroin and/or cocaine addiction. Subjects & methods: The study examined 140 polymorphisms in 19 genes in 1855 subjects with predominantly European or African ancestries. Results: A total of 38 polymorphisms (13 genes) showed nominal associations, including novel associations in S100A10 (p11) and SLC18A2 (VMAT2). The association of HTR3B SNP rs11606194 with heroin addiction in the European ancestry subgroup remained significant after correction for multiple testing (p _corrected = 0.04). Conclusion: The study strengthens our previous findings of association of polymorphisms in HTR3A, HTR3B and ADRA1A. The study suggests partial overlap in genetic susceptibility between populations of different ancestry and between heroin and cocaine addiction.

Original language	English
Pages (from-to)	1329-1342
Number of pages	14
Journal	Pharmacogenomics
Volume	16
Issue number	12
DOIs	https://doi.org/10.2217/pgs.15.86
State	Published - 1 Aug 2015
Externally published	Yes

Keywords

ADRA1A
African-American
HTR3A
HTR3B
S100A10
SLC18A2
SLC6A4
adrenergic pathway
association study
cocaine addiction
genetic variants
heroin addiction
serotonergic pathway
stress

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10.2217/pgs.15.86

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title = "Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry",

abstract = "Background: Drug addiction is influenced by genetic factors. Aim: To determine if genetic variants in the serotonergic and adrenergic pathways are associated with heroin and/or cocaine addiction. Subjects \& methods: The study examined 140 polymorphisms in 19 genes in 1855 subjects with predominantly European or African ancestries. Results: A total of 38 polymorphisms (13 genes) showed nominal associations, including novel associations in S100A10 (p11) and SLC18A2 (VMAT2). The association of HTR3B SNP rs11606194 with heroin addiction in the European ancestry subgroup remained significant after correction for multiple testing (p corrected = 0.04). Conclusion: The study strengthens our previous findings of association of polymorphisms in HTR3A, HTR3B and ADRA1A. The study suggests partial overlap in genetic susceptibility between populations of different ancestry and between heroin and cocaine addiction.",

keywords = "ADRA1A, African-American, HTR3A, HTR3B, S100A10, SLC18A2, SLC6A4, adrenergic pathway, association study, cocaine addiction, genetic variants, heroin addiction, serotonergic pathway, stress",

author = "Orna Levran and Einat Peles and Matthew Randesi and \{Correa Da Rosa\}, Joel and Jurg Ott and John Rotrosen and Miriam Adelson and Kreek, \{Mary Jeanne\}",

note = "Publisher Copyright: {\textcopyright} 2015 Future Medicine Ltd.",

year = "2015",

month = aug,

day = "1",

doi = "10.2217/pgs.15.86",

language = "English",

volume = "16",

pages = "1329--1342",

journal = "Pharmacogenomics",

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publisher = "Taylor and Francis Ltd.",

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TY - JOUR

T1 - Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry

AU - Levran, Orna

AU - Peles, Einat

AU - Randesi, Matthew

AU - Correa Da Rosa, Joel

AU - Ott, Jurg

AU - Rotrosen, John

AU - Adelson, Miriam

AU - Kreek, Mary Jeanne

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Background: Drug addiction is influenced by genetic factors. Aim: To determine if genetic variants in the serotonergic and adrenergic pathways are associated with heroin and/or cocaine addiction. Subjects & methods: The study examined 140 polymorphisms in 19 genes in 1855 subjects with predominantly European or African ancestries. Results: A total of 38 polymorphisms (13 genes) showed nominal associations, including novel associations in S100A10 (p11) and SLC18A2 (VMAT2). The association of HTR3B SNP rs11606194 with heroin addiction in the European ancestry subgroup remained significant after correction for multiple testing (p corrected = 0.04). Conclusion: The study strengthens our previous findings of association of polymorphisms in HTR3A, HTR3B and ADRA1A. The study suggests partial overlap in genetic susceptibility between populations of different ancestry and between heroin and cocaine addiction.

AB - Background: Drug addiction is influenced by genetic factors. Aim: To determine if genetic variants in the serotonergic and adrenergic pathways are associated with heroin and/or cocaine addiction. Subjects & methods: The study examined 140 polymorphisms in 19 genes in 1855 subjects with predominantly European or African ancestries. Results: A total of 38 polymorphisms (13 genes) showed nominal associations, including novel associations in S100A10 (p11) and SLC18A2 (VMAT2). The association of HTR3B SNP rs11606194 with heroin addiction in the European ancestry subgroup remained significant after correction for multiple testing (p corrected = 0.04). Conclusion: The study strengthens our previous findings of association of polymorphisms in HTR3A, HTR3B and ADRA1A. The study suggests partial overlap in genetic susceptibility between populations of different ancestry and between heroin and cocaine addiction.

KW - ADRA1A

KW - African-American

KW - HTR3A

KW - HTR3B

KW - S100A10

KW - SLC18A2

KW - SLC6A4

KW - adrenergic pathway

KW - association study

KW - cocaine addiction

KW - genetic variants

KW - heroin addiction

KW - serotonergic pathway

KW - stress

UR - https://www.scopus.com/pages/publications/84941624380

U2 - 10.2217/pgs.15.86

DO - 10.2217/pgs.15.86

M3 - Article

C2 - 26227246

AN - SCOPUS:84941624380

SN - 1462-2416

VL - 16

SP - 1329

EP - 1342

JO - Pharmacogenomics

JF - Pharmacogenomics

IS - 12

ER -

Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry

Abstract

Keywords

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