Survival outcomes in early stage laryngeal cancer

Uchechukwu C. Megwalu, Haig Panossian

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Aim: To evaluate survival outcomes of radiotherapy versus surgical resection in the treatment of early stage laryngeal cancer. Patients and Methods: Data was extracted from the Surveillance, Epidemiology, and End Results 18 Database. The cohort included 5,301 patients diagnosed with stages I and II laryngeal squamous cell carcinoma between 1992 and 2009, treated with either surgical therapy or radiotherapy. Results: Patients who received surgical therapy had better overall survival (OS) than patients who received radiation therapy (p<0.001). The difference in OS between treatment groups remained after stratification by stage (p<0.001 for Stage I; p=0.03 for Stage II) and subsite (p<0.001). On multivariable analysis, the radiotherapy group had worse OS (hazard ratio (HR)=1.29). Conclusion: Patients with early-stage laryngeal cancer treated with surgical therapy have better survival outcomes than patients treated with non-surgical therapy.

Original languageEnglish
Pages (from-to)2903-2907
Number of pages5
JournalAnticancer Research
Volume36
Issue number6
StatePublished - Jun 2016
Externally publishedYes

Keywords

  • Comparative effectiveness
  • Laryngeal cancer
  • SEER database
  • Survival
  • Therapy

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